School of Medicine
Neurosciences
 

Dominique Durand, Ph.D.

Dominique Durand, Ph.D.
Professor, Department of Biomedical Engineering
Neural Engineering Center and Biomedical Engineering Department
Case Western Reserve University

Room 112 Wickenden Building
Department of Biomedical Engineering
Neural Engineering Center
Cleveland OH, 44106-4975

Phone : (216) 368-3974
Fax : (216) 368-4872
Email : dominique.durand@case.edu
 
 

RESEARCH INTERESTS

Neural Engineering is a new discipline at the interface between engineering and neuroscience. Neural Engineering research in my laboratory combines computational neuroscience, engineering and electrophysiology to solve problems in the central and peripheral nervous systems.

In the CNS, the mechanisms of synchronization of neuronal activity during epilepsy are investigated using in-vitro brain slice preparations, in-vivo multiple electrode recording and computer models. The interaction between applied currents and neuronal tissue are studied to determine the feasibility of controlling seizures in patients with epilepsy.

In the peripheral nervous system, novel nerve electrodes are being developed capable of stimulating and recording neuronal activity selectively. This neural interfacing methodology is applied to the hypoglossal nerve to restore patency in the airways in patients with obstructive sleep apnea and to design neural prostheses for patients with spinal cord injury and stroke. Computer simulations of both neurons and volume conductors are used in conjunction with the experiments for the quantitative analysis of neural systems and to design new electrodes for interfacing with the nervous system.

SELECTED PUBLICATIONS

  1. Leventhal DK, Cohen M, Durand DM. (2006)
    Chronic histological effects of the flat interface nerve electrode. J Neural Eng. 2006 Jun; 3(2):102-113. 2006/04/18 [aheadofprint].
  2. Lertmanorat Z, Gustafson KJ, Durand DM. (2006)
    Electrode array for reversing the recruitment order of peripheral nerve stimulation: experimental studies. Ann Biomed Eng. 2006 Jan; 34(1):152-160. 2006/02/02 [aheadofprint].
  3. Yoo PB, Durand DM. (2005)
    Selective recording of the canine hypoglossal nerve using a multicontact flat interface nerve electrode. IEEE Trans Biomed Eng. 2005 Aug; 52(8):1461-1469.
  4. Park EH, Durand DM. (2006)
    Role of potassium lateral diffusion in non-synaptic epilepsy: a computational study. J Theor Biol. 2006 Feb 7; 238(3):666-682. 2005/08/08 [aheadofprint].
  5. Lertmanorat Z, Durand DM. (2004)
    Extracellular voltage profile for reversing the recruitment order of peripheral nerve stimulation: a simulation study. J Neural Eng. 2004 Dec; 1(4):202-211. 2004/11/17 [aheadofprint].
  6. Lian J, Shuai J, Durand DM. (2004)
    Control of phase synchronization of neuronal activity in the rat hippocampus. J Neural Eng. 2004 Mar; 1(1):46-54. 2004/03/15 [aheadofprint].
  7. Yoo PB, Durand DM. (2005)
    Effects of selective hypoglossal nerve stimulation on canine upper airway mechanics. J Appl Physiol. 2005 Sep; 99(3):937-943. 2005/04/14 [aheadofprint].
  8. Feng Z, Durand DM. (2004)
    Suppression of excitatory synaptic transmission can facilitate low-calcium epileptiform activity in the hippocampus in vivo. Brain Res. 2004 Dec 24; 1030(1):57-65. 2004/09/27 [accepted].
  9. Feng Z, Durand DM. (2005)
    Decrease in synaptic transmission can reverse the propagation direction of epileptiform activity in hippocampus in vivo. J Neurophysiol. 2005 Mar; 93(3):1158-1164. 2004/10/20 [aheadofprint].
  10. Leventhal DK, Durand DM. (2004)
    Chronic measurement of the stimulation selectivity of the flat interface nerve electrode. IEEE Trans Biomed Eng. 2004 Sep; 51(9):1649-1658.
  11. Lertmanorat Z, Durand DM. (2004)
    A novel electrode array for diameter-dependent control of axonal excitability: a simulation study. IEEE Trans Biomed Eng. 2004 Jul; 51(7):1242-1250.
  12. Yoo PB, Sahin M, Durand DM. (2004)
    Selective stimulation of the canine hypoglossal nerve using a multi-contact cuff electrode. Ann Biomed Eng. 2004 Apr; 32(4):511-519.
  13. Durand DM. (2003)
    Electric field effects in hyperexcitable neural tissue: a review. Radiat Prot Dosimetry. 2003; 106(4):325-331.
  14. Hsu KH, Nagarajan SS, Durand DM. (2003)
    Analysis of efficiency of magnetic stimulation. IEEE Trans Biomed Eng. 2003 Nov; 50(11):1276-1285.
  15. Feng Z, Durand DM. (2003)
    Low-calcium epileptiform activity in the hippocampus in vivo. J Neurophysiol. 2003 Oct; 90(4):2253-2260.
  16. Leventhal DK, Durand DM. (2003)
    Subfascicle stimulation selectivity with the flat interface nerve electrode. Ann Biomed Eng. 2003 Jun; 31(6):643-652.
  17. Tyler DJ, Durand DM. (2003)
    Chronic response of the rat sciatic nerve to the flat interface nerve electrode. Ann Biomed Eng. 2003 Jun; 31(6):633-642.
  18. Tyler DJ, Durand DM. (2002)
    Functionally selective peripheral nerve stimulation with a flat interface nerve electrode. IEEE Trans Neural Syst Rehabil Eng. 2002 Dec; 10(4):294-303.
  19. Shuai J, Bikson M, Hahn PJ, Lian J, Durand DM. (2003)
    Ionic mechanisms underlying spontaneous CA1 neuronal firing in Ca2+-free solution. Biophys J. 2003 Mar; 84(3):2099-2111.
  20. Lian J, Bikson M, Sciortino C, Stacey WC, Durand DM. (2003)
    Local suppression of epileptiform activity by electrical stimulation in rat hippocampus in vitro. J Physiol. 2003 Mar 1; 547(Pt 2):427-434. 2003/01/24 [aheadofprint].
  21. Stacey WC, Durand DM. (2002)
    Noise and coupling affect signal detection and bursting in a simulated physiological neural network. J Neurophysiol. 2002 Nov; 88(5):2598-2611.
  22. Bikson M, Baraban SC, Durand DM. (2002)
    Conditions sufficient for nonsynaptic epileptogenesis in the CA1 region of hippocampal slices. J Neurophysiol. 2002 Jan; 87(1):62-71.
  23. Lian J, Bikson M, Shuai J, Durand DM. (2001)
    Propagation of non-synaptic epileptiform activity across a lesion in rat hippocampal slices. J Physiol. 2001 Nov 15; 537(Pt 1):191-199.
  24. Hsu KH, Durand DM. (2001)
    A 3-D differential coil design for localized magnetic stimulation. IEEE Trans Biomed Eng. 2001 Oct; 48(10):1162-1168.
  25. Stacey WC, Durand DM. (2001)
    Synaptic noise improves detection of subthreshold signals in hippocampal CA1 neurons. J Neurophysiol. 2001 Sep; 86(3):1104-1112.
  26. Hahn PJ, Durand DM. (2001)
    Bistability dynamics in simulations of neural activity in high-extracellular-potassium conditions. J Comput Neurosci. 2001 Jul-Aug; 11(1):5-18.
  27. Shuai JW, Lian J, Hahn PJ, Durand DM. (2001)
    Positive Lyapunov exponents calculated from time series of strange nonchaotic attractors. Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Aug; 64(2 Pt 2):026220. 2001/07/23 [aheadofprint].
  28. Carbunaru R, Durand DM. (2001)
    Toroidal coil models for transcutaneous magnetic stimulation of nerves. IEEE Trans Biomed Eng. 2001 Apr; 48(4):434-441.
  29. Choi AQ, Cavanaugh JK, Durand DM. (2001)
    Selectivity of multiple-contact nerve cuff electrodes: a simulation analysis. IEEE Trans Biomed Eng. 2001 Feb; 48(2):165-172.
  30. Bikson M, Lian J, Hahn PJ, Stacey WC, Sciortino C, Durand DM. (2001)
    Suppression of epileptiform activity by high frequency sinusoidal fields in rat hippocampal slices. J Physiol. 2001 Feb 15; 531(Pt 1):181-191.
  31. Lian J, Shuai J, Hahn P, Durand DM. (2001)
    Nonlinear dynamic properties of low calcium-induced epileptiform activity. Brain Res. 2001 Feb 2; 890(2):246-254.
  32. Perez-Orive J, Durand DM. (2000)
    Modeling study of peripheral nerve recording selectivity. IEEE Trans Rehabil Eng. 2000 Sep; 8(3):320-329.
  33. Sahin M, Durand DM, Haxhiu MA. (2000)
    Closed-loop stimulation of hypoglossal nerve in a dog model of upper airway obstruction. IEEE Trans Biomed Eng. 2000 Jul; 47(7):919-925.
  34. Ghai RS, Bikson M, Durand DM. (2000)
    Effects of applied electric fields on low-calcium epileptiform activity in the CA1 region of rat hippocampal slices. J Neurophysiol. 2000 Jul; 84(1):274-280.
  35. Cuoco FA Jr, Durand DM. (2000)
    Measurement of external pressures generated by nerve cuff electrodes. IEEE Trans Rehabil Eng. 2000 Mar; 8(1):35-41.
  36. Hsu KH, Durand DM. (2000)
    Prediction of neural excitation during magnetic stimulation using passive cable models. IEEE Trans Biomed Eng. 2000 Apr; 47(4):463-471.
  37. Stacey WC, Durand DM. (2000)
    Stochastic resonance improves signal detection in hippocampal CA1 neurons. J Neurophysiol. 2000 Mar; 83(3):1394-1402.

POSTDOCTORAL FELLOW FIRST AUTHORED PAPERS

  1. Qi H, Tyler DJ, Durand DM. (1999)
    Neurofuzzy adaptive controlling of selective stimulation for FES: a case study. IEEE Trans Rehabil Eng. 1999 Jun; 7(2):183-192.

GRADUATE STUDENT FIRST AUTHOR PUBLICATIONS

  1. Carbunaru R, Durand DM. (2001)
    Toroidal coil models for transcutaneous magnetic stimulation of nerves. IEEE Trans Biomed Eng. 2001 Apr; 48(4):434-441.
  2. Bikson M, Lian J, Hahn PJ, Stacey WC, Sciortino C, Durand DM. (2001)
    Suppression of epileptiform activity by high frequency sinusoidal fields in rat hippocampal slices. J Physiol. 2001 Feb 15; 531(Pt 1):181-191.
  3. Perez-Orive J, Durand DM. (2000)
    Modeling study of peripheral nerve recording selectivity. IEEE Trans Rehabil Eng. 2000 Sep; 8(3):320-329.
  4. Sahin M, Durand DM, Haxhiu MA. (2000)
    Closed-loop stimulation of hypoglossal nerve in a dog model of upper airway obstruction. IEEE Trans Biomed Eng. 2000 Jul; 47(7):919-925.
  5. Ghai RS, Bikson M, Durand DM. (2000)
    Effects of applied electric fields on low-calcium epileptiform activity in the CA1 region of rat hippocampal slices. J Neurophysiol. 2000 Jul; 84(1):274-280.
  6. Hsu KH, Durand DM. (2000)
    Prediction of neural excitation during magnetic stimulation using passive cable models. IEEE Trans Biomed Eng. 2000 Apr; 47(4):463-471.
  7. Stacey WC, Durand DM. (2000)
    Stochastic resonance improves signal detection in hippocampal CA1 neurons. J Neurophysiol. 2000 Mar; 83(3):1394-1402.
  8. Sahin M, Durand DM, Haxhiu MA. (1999)
    Chronic recordings of hypoglossal nerve activity in a dog model of upper airway obstruction. J Appl Physiol. 1999 Dec; 87(6):2197-2206.
  9. Bikson M, Ghai RS, Baraban SC, Durand DM. (1999)
    Modulation of burst frequency, duration, and amplitude in the zero-Ca(2+) model of epileptiform activity. J Neurophysiol. 1999 Nov; 82(5):2262-2270.
  10. Patil MM, Durand DM, LaManna JC, Whittingham TS, Haxhiu MA. (1999)
    Effects of oxygen deprivation on parapyramidal neurons of the ventrolateral medulla in the rat. Respir Physiol. 1999 Jan 1; 115(1):11-22.
  11. Warren RJ, Durand DM. (1998)
    Effects of applied currents on spontaneous epileptiform activity induced by low calcium in the rat hippocampus. Brain Res. 1998 Sep 28; 806(2):186-195.
  12. Sahin M, Durand DM. (1998)
    Improved nerve cuff electrode recordings with subthreshold anodic currents. IEEE Trans Biomed Eng. 1998 Aug; 45(8):1044-1050.
  13. Carbunaru R, Durand DM. (1997)
    Axonal stimulation under MRI magnetic field z gradients: a modeling study. Magn Reson Med. 1997 Nov; 38(5):750-758.
  14. Lyubkin M, Durand DM, Haxhiu MA. (1997)
    Interaction between tetanus long-term potentiation and hypoxia-induced potentiation in the rat hippocampus. J Neurophysiol. 1997 Nov; 78(5):2475-2482.
  15. Sahin M, Haxhiu MA, Durand DM, Dreshaj IA. (1997)
    Spiral nerve cuff electrode for recordings of respiratory output. J Appl Physiol. 1997 Jul; 83(1):317-322.
  16. Tyler DJ, Durand DM. (1997)
    A slowly penetrating interfascicular nerve electrode for selective activation of peripheral nerves. IEEE Trans Rehabil Eng. 1997 Mar; 5(1):51-61.
  17. Nagarajan SS, Durand DM, Hsuing-Hsu K. (1997)
    Mapping location of excitation during magnetic stimulation: effects of coil position. Ann Biomed Eng. 1997 Jan-Feb; 25(1):112-125.
  18. Nagarajan SS, Durand DM. (1995)
    Analysis of magnetic stimulation of a concentric axon in a nerve bundle. IEEE Trans Biomed Eng. 1995 Sep; 42(9):926-933.
  19. Nagarajan SS, Durand DM, Roth BJ, Wijesinghe RS. (1995)
    Magnetic stimulation of axons in a nerve bundle: effects of current redistribution in the bundle. Ann Biomed Eng. 1995 Mar-Apr; 23(2):116-126.

JOB PLACEMENT OF STUDENTS AND POSTDOCS

Postdoc or R.A. / PeriodCurrent Position
Mesut Sahin
Jul-98 to		Research Associate
Jian-Wei Shuai
Jun-98 to		Research Associate
Johannes Strujk
Jul-98 to		Visiting Professor (University of Aalborg),
Associate Professor, Aalborg University
Lin, Jian-Cheng
Oct94-98		Senior Research Associate
Qi, Haiming
Oct96-98		Senior Res. Associate,
Research associate, University of British Colombia)
Tawfik, Bassel
Jul97-Sep97		Visiting Professor,
Associate professor, (University of Cairo)

 

Ph.D. Student / GradThesis / Current Position
Srikantan Nagaranjan
Dec-94		“Theoretical and Experimental Analysis of Magnetic stimulation of Neuronal System.”
Assistant Professor, University of Utah, Biomedical Engineering.
Madhavi Patil
May-95		 “Effect of hypoxia on the nervous system.”
Post-doctoral fellow, Harvard University.
Mesut Sahin
May-98		“Chronic recording and stimulation of the hypoglossal nerve in dogs for obstructive sleep apnea.”
Research Associate, CWRU, Biomedical Engineering.
Anila Jahangiri
May-98		“Phase Resetting analysis of high potassium epileptiforma activity.”
Engineer: VI Engineering, Inc.
Dustin Tyler
May-99		“Functional Electrical Stimulation of Peripheral nerve: electrodes that alter nerve geometry.”
Scientist, Neurocontrol, Inc.
Rafael Carbunaru
May-99		“Coil design for efficient and localized magnetic stimulation of the nervous system.”
Research Scientist, Advanced Bionics.
Kai-Hsiung Hsu
Aug-00		“Analysis of excitation characteristics of Magnetic stimulation.”
William Stacey
Aug-00		“Stochastic resonance in the hippocampus.”
Medical Student, CWRU

 

Ms.C. Student / GradThesis / Current Position
K.S. Hsu
May-96		“Determination of excitation of nerve fibers during magnetic stimulation.”
J. Cavanaugh
May-96		“Finite element analysis of electrical nerve stimulation.”
Engineer, General Electric.
Frank Cuoco
May-96		“Measurement of external pressure generated by nerve electrodes.”
Medical Student Georgetown University
Rafael Carbunaru
May-96		“Axonal stimulation under MRI Z-gradient magnetic fields: a modelling study.”
Scientist, Advanced Bionics.
Jim Warren
Dec-96		“Control of low calcium activity with applied currents.”

Medical Student, University of Cincinnati.

Albert Guzman
Dec-97		“Detection of tactile slip using the power spectrum of spiral cuff recordings from sensory nerve.”
Engineer, Cyberonics.
Rahul S. Ghai
May-98		“Electric field suppression of spontaneous low calcium epileptifirm activity in the CA1 region of rat hippocampal slices.”
Consultant, Deloitte and Touche.
J. Perez Orive
Dec-98		“Modelling study of peripheral nerve recording selectivity.”
Graduate student, California Institute of Technology.
Adam Choi
Dec-98		Nerve electrode design for improved selectivity.”
Andrea Oates
May-00		“Measurement of the impedance of the Dura matter.”

 

 
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