Department of Pediatrics / Neonatology and Neurosciences
Case Western Reserve University
11100 Euclid Ave
RB&C Suite 3100
Cleveland OH, 44106-6010
My laboratory is primarily interested in the generation and modulation of respiratory rhythm in the mammalian central nervous system. The questions we seek to answer are: How does the brain generate the drive for breathing? How is breathing pattern modulated by reflexes and chemosensation? What are the neural pathways involved in breathing? What are the biophysical properties of cells involved in breathing? How does respiratory drive change as we age?
We use electrophysiology techniques (extracellular single-unit recording, whole cell patch-clamp, electrochemistry) and fluorescence imaging (calcium indicators, pH sensitive dyes) to explore the dynamic relationship between cells that are phasically active during breathing. Our chief animal model is the developing rat but we also use mice to explore genetic variability in the respiratory neural substrate. Recently we have embarked on a series of experiments designed to quantify how neurons and astrocytes communicate with each other to modulate respiration as we age.
CA Mayer, MA Haxhiu, RJ Martin, CG Wilson. (2006)
Adenosine A2A receptors mediate GABAergic inhibition of respiration in immature rats. J. Appl. Physiol. Jan; 100(1):91-7. (Epub 2005 Sep 1).
Young JK, Dreshaj IA, Wilson CG, Martin RJ, Zaidi SI, Haxhiu MA. (2005)
An astrocyte toxin influences the pattern of breathing and the ventilatory response to hypercapnia in neonatal rats. Respir Physiol Neurobiol. May 12; 147(1):19-30.
Haxhiu MA, Kc P, Moore CT, Acquah SS, Wilson CG, Zaidi SI, Massari VJ, Ferguson DG. (2005)
Brain stem excitatory and inhibitory signaling pathways regulating bronchoconstrictive responses. J Appl Physiol. Jun; 98(6):1961-82.
I Gonsenhauser, CG Wilson, H Fang, KP Strohl, TE Dick. (2004)
Strain Differences in Murine Ventilatory Behavior Persist after Urethane Anesthesia. J. Appl. Physiol. 97:888-894.
CG Wilson, RJ Martin, M Jaber, J Abu-Shaweesh, A Jafri, MA Haxhiu, S Zaidi. (2004)
Adenosine A2A receptors interact with GABAergic pathways to modulate respiration in neonatal piglets. Resp Physiol. Neurobiol. 141:201-211.
CT Moore, CG Wilson, CA Mayer, SS Acquah, VJ Massari, MA Haxhiu. (2004)
GABAergic inhibitory microcircuit controlling cholinergic outflow to the airways. J. Appl. Physiol. 96:260-270. (First published Sept. 12, 2003 online)..
CA Del Negro, CG Wilson, RJ Butera, H Rigatto, JC Smith. (2002)
Periodicity, mixed-mode oscillations, and quasiperiodicity in a rhythm-generating neural network. Biophys Journal. 82(1 Pt 1):206-14.
CG Wilson, RJ Butera, Jr., CA Del Negro, J Rinzel, and JC Smith. (2001)
Interfacing computer models with real neurons: respiratory cyberneurons' created with the dynamic clamp. Adv Exp Med Biol. 2001; 499:119-24.